Foto del docente

Federico Falchi

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: CHEM-07/A Pharmaceutical Chemistry

Publications

Sebastiano Rupiani; Rosa Buonfiglio; Marcella Manerba; Lorenza Di Ianni; Marina Vettraino; Elisa Giacomini; Matteo Masetti; Federico Falchi; Giuseppina Di Stefano; Marinella Roberti; Maurizio Recanatini, Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2015, 101, pp. 63 - 70 [Scientific article]

Tintori C.; La Sala G.; Vignaroli G.; Botta L.; Fallacara A.L.; Falchi F.; Radi M.; Zamperini C.; Dreassi E.; Dello Iacono L.; Orioli D.; Biamonti G.; Garbelli M.; Lossani A.; Gasparrini F.; Tuccinardi T.; Laurenzana I.; Angelucci A.; Maga G.; Schenone S.; Brullo C.; Musumeci F.; Desogus A.; Crespan E.; Botta M., Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors, «JOURNAL OF MEDICINAL CHEMISTRY», 2015, 58, pp. 4590 - 4609 [Scientific article]

Prati, Federica; Bergamini, Christian; Molina, Maria Teresa; Falchi, Federico; Cavalli, Andrea; Kaiser, Marcel; Brun, Reto; Fato, Romana; Bolognesi, Maria Laura, 2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile, «JOURNAL OF MEDICINAL CHEMISTRY», 2015, 58, pp. 6422 - 6434 [Scientific article]

Giacomini E;Nebbioso A;Ciotta A;Ianni C;Falchi F;Roberti M;Tolomeo M;Grimaudo S;Cristina AD;Pipitone RM;Altucci L;Recanatini M, Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity., «ACS MEDICINAL CHEMISTRY LETTERS», 2014, 5, pp. 973 - 978 [Scientific article]

Patent n. WO/2014/187777, NOVEL INHIBITORS OF PVHL-ELONGIN C BINDING.

Matteo Masetti;Federico Falchi;Maurizio Recanatini, Protein Dynamics of the HIF-2α PAS-B Domain upon Heterodimerization and Ligand Binding, «PLOS ONE», 2014, 9, pp. e94986 - e94986 [Scientific article]Open Access

Federico Falchi;Fabiana Caporuscio;Maurizio Recanatini, Structure-based design of small-molecule protein–protein interaction modulators: the story so far, «FUTURE MEDICINAL CHEMISTRY», 2014, 6, pp. 343 - 357 [Scientific article]

R. Buonfiglio; M. Ferraro; F. Falchi; A. Cavalli; M. Masetti; M. Recanatini, Collecting and assessing human lactate dehydrogenase-A conformations for structure-based virtual screening, «JOURNAL OF CHEMICAL INFORMATION AND MODELING», 2013, 53, pp. 2792 - 2797 [Scientific article]

Tintori C.; Laurenzana I.; LaRocca F.; Falchi F.; Carraro F.; Ruiz A.; Este J.A.; Kissova M.; Crespan E.; Maga G.; Biava M.; Brullo C.; Schenone S.; Botta M., Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti-HIV Agents, «CHEMMEDCHEM», 2013, 8, pp. 1353 - 1360 [Scientific article]

Radi M.; Evensen L.; Dreassi E.; Zamperini C.; Caporicci M.; Falchi F.; Musumeci F.; Schenone S.; Lorens J.B.; Botta M., A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation, «BIOORGANIC & MEDICINAL CHEMISTRY LETTERS», 2012, 22, pp. 5579 - 5583 [Scientific article]

Radi M.; Falchi F.; Garbelli A.; Samuele A.; Bernardo V.; Paolucci S.; Baldanti F.; Schenone S.; Manetti F.; Maga G.; Botta M., Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors, «BIOORGANIC & MEDICINAL CHEMISTRY LETTERS», 2012, 22, pp. 2094 - 2098 [Scientific article]

Giovanni Maga, Anna Garbelli, Marco Radi, Federico Falchi, Alberta Samuele, Stefania Paolucci, Fausto Baldanti, Fabrizio Manetti, Sandra Beermann, Ursula Dietrich, Maurizio Botta, Next generation of antiretroviral agents targeting the RNA binding site of the HIV-1 cellular cofactor DDX3: an innovative therapeutic approach, «RETROVIROLOGY», 2012, 9, pp. 1 - 1 [Scientific article]

Patent n. WO/2011/039735, COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF.

Corradi V; Mancini M; Santucci MA; Carlomagno T; Sanfelice D; Mori M; Vignaroli G; Falchi F; Manetti F; Radi M; Botta M, Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case, «BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS», 2011, 21, pp. 6867 - 6871 [Scientific article]

Schenone S.; Brullo C.; Musumeci F.; Biava M.; Falchi F.; Botta M., Fyn kinase in brain diseases and cancer: The search for inhibitors, «CURRENT MEDICINAL CHEMISTRY», 2011, 18, pp. 2921 - 2942 [Scientific article]

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