Argomenti di tesi proposti dal docente.
- Tesi in azienda. Lo scambiatore di calore passivo a lastre piane, l'idea è quella di paragonare lo scambiatore di calore utilizzato dall'azienda con uno commerciale e vedere quale dei due possiede un rendimento maggiore ed eventualmente anche lavorare sulla ottimizzazione della geometria.
- Overcoming Rs compensation limits in patch clamp electrophysiological recordings (with internship at Elements srl)
- Computational analysis of the role of potassium repolarizing currents in a model of human Purkinjie action potential
- Computational analysis of If current in hiPS-CMs (starting from the paper: A detailed characterization of the hyperpolarization-activated "funny" current (I ) in human-induced pluripotent stem cell (iPSC)-derived cardiomyocytes with pacemaker activity. [https://pubmed.ncbi.nlm.nih.gov/33934225/] Giannetti F, Benzoni P, Campostrini G, Milanesi R, Bucchi A, Baruscotti M, Dell'Era P, Rossini A, Barbuti A. Pflugers Arch. 2021)
- Computational modeling of heart failure in isolated cardiomyocytes: distinguishing HF with reduced and preserved ejection fraction (starting from the paper: Distinguishing HF with reduced and preserved ejection fraction at the level of individual cardiomyocytes: implications for therapeutic development. [https://pubmed.ncbi.nlm.nih.gov/33017063/] Durland L. J Physiol. 2021)
- Regulatory issues in medical devices (specific topic to be defined in collaboration with Thema company)
- Design and implementation of a Simulink library of Action Potential models
The aim is to develop a Simulink library (Blockset) in which AP models are implement in a modular way (e.g.: one block for each current), which will facilitate comparison of models, as well as testing of hybrid models.
- Computational analysis of virtual ablations or fast conduction pathways insertions in a 2-dimensional atrial tissue.
A portion of cardiac tissue will be simulated. Protocols to induce sustained electrical activation (resembling atrial fibrillation) will be implemented. The effectiveness of different ablation strategies in stopping fibrillation will be analysed, as well as the effect of the insertion of fast conduction pathways.
- Design and development of a Health Technology Management system for hospitals in low resource settings at the St. Luke Hospital in Wolisso, Ethiopia (within a Global South funded project)
- Extracellular Ca2+ variation effect on electro-mechanically coupled human atrial cardiomyocytes computational model.
The project will be based on our newly developed model, MBS2022 and dealing with GHK formulation of the ICaL current driving force. The objective is to obtain correct APD-[Ca2+]o dependence for human atrial electromechanically coupled cardiomyocyte model.
- Investigating the genetic factors behind the pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy (HCM) using electromechanically coupled human atrial model.
- Development, Implementation and Testing of a Multicellular Dynamic Action Potential Clamp Simulator for Drug Cardiac Safety Assessment
Ultime tesi seguite dal docente
Tesi di Laurea
- Analisi del livello di informatizzazione delle strutture ospedaliere private nella regione Lazio
- Health Technology Management in contesti a risorse limitate: il progetto Global South presso il St. Luke Catholic Hospital di Wolisso
- Modulazione della contrattilità cardiaca, una tecnica innovativa per il trattamento dell’insufficienza cardiaca
- protesi acustiche: storia ed evoluzione
- Studio della modulazione della contrattilità cardiaca per il trattamento dell'insufficienza cardiaca mediante l'utilizzo di modelli computazionali del potenziale d'azione
Tesi di Laurea Magistrale
- "MDR Compliance in the Production of Customized Phantoms through 3D Printing: Drafting of the Operating Procedure and Illustrative Clinical Case"
- A new mechanism to deform Red Blood Cells
- A novel formulation for the small-conductance calcium-activated potassium current for a computational model of the action potential for the cardiac pacemaker cell
- Analog and digital solutions for the implementation of a wearable device for the measurement of ECG and transthoracic impedance
- Computational analysis of virtual ablation or fast conduction pathways insertion in a 2-dimensional atrial tissue
- Computational simulation of ischemia-induced hyperkalemia using the BPS human ventricular action potential model
- Computational Study of the Role of Funny
Current in Atrioventricular Conduction by Multiscale Mouse Heart Models
- Development and on-site implementation and user training of a simple Health Technology Management System in a low-resource setting
- Development and testing of a digital health assistant for pediatric asthma patients
- FDA guidance implementation for Cybersecurity in medical devices: drafting the Premarket Submission of the innovative Medis QFR 3.0 cardiac imaging software.
- Implementation of the effects of hypertension in a patient-level model of atrial fibrillation
- Improving Automated Analysis of Quantal Release Events: Optimization of APE Code for Enhanced Data Processing in Diamond Multi-Electrode Arrays
- Investigating oral anticoagulation therapy in AF patient level models
- Pulmonary Vein Isolation for Atrial Fibrillation: Comparing Performances of High Power and Low Power Modes and Evaluating 1-Month Clinical Outcomes
- Registration of non-active invasive medical devices used for dental regenerative applications in Indian medical market
- Regulatory Frameworks and Compliance of Dental Implants: A Global Perspective with Focus on Vietnam
Tesi di Dottorato
- Modelling the sinoatrial node across the scales: the role of heterogeneity in pacemaking and atrial driving
