Masi, Mirco; Poppi, Laura; Previtali, Viola; Nelson, Shannon R; Wynne, Kieran; Varignani, Giulia; Falchi, Federico; Veronesi, Marina; Albanesi, Ennio; Tedesco, Daniele; De Franco, Francesca; Ciamarone, Andrea; Myers, Samuel H; Ortega, Jose Antonio; Bagnolini, Greta; Ferrandi, Giovanni; Farabegoli, Fulvia; Tirelli, Nicola; Di Stefano, Giuseppina; Oliviero, Giorgio; Walsh, Naomi; Roberti, Marinella; Girotto, Stefania; Cavalli, Andrea, Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity, «CELL DEATH DISCOVERY», 2025, 11, Article number: 106 , pp. 1 - 23 [Scientific article]Open Access
Previtali, Viola; Masi, Mirco; Poppi, Laura; Varignani, Giulia; Falchi, Federico; Tedesco, Daniele; Wynne, Kieran; Oliviero, Giorgio; Bagnolini, Greta; Farabegoli, Fulvia; DI STEFANO, Giuseppina; Girotto, Stefania; Roberti, Marinella; Cavalli, Andrea, Differential enantiomers activity of ARN24089 to achieve synthetic lethality in pancreatic cancer, in: 1, 2024(atti di: EFMC ISMC XXVIII EFMC International Symposium on Medicinal Chemistry, Rome, 1-5 September 2024) [Poster]
Rossi, V.; Hochkoeppler, A.; Govoni, M.; Di Stefano, G., Lactate-Induced HBEGF Shedding and EGFR Activation: Paving the Way to a New Anticancer Therapeutic Opportunity, «CELLS», 2024, 13, Article number: 1533 , pp. 1 - 21 [Scientific article]Open Access
Stefan, Alessandra; Gentilucci, Luca; Ruffolo, Francesca; Rossi, Valentina; Sordi, Sofia; He, Tingting; di Stefano, Giuseppina; Santino, Federica; Brigotti, Maurizio; Scotti, Claudia; Iamele, Luisa; de Jonge, Hugo; Piaz, Fabrizio Dal; Santarcangelo, Danilo Rocco; Hochkoeppler, Alejandro, Peptides inhibiting the assembly of monomeric human l‐lactate dehydrogenase into catalytically active homotetramer decrease the synthesis of lactate in cultured cells, «PROTEIN SCIENCE», 2024, 33, Article number: e5161 , pp. 1 - 26 [Scientific article]Open Access
Laura Poppi, Samuel H Myers, Viola Previtali, Francesco Rinaldi, Fulvia Farabegoli, Giuseppina Di Stefano, Naomi Walsh, Marinella Roberti, Andrea Cavalli, A RAD51/BRCA2 small molecule inhibitor enhances the antineoplastic effect of the PARPi talazoparib in pancreatic cancer, in: EACR 2023: Innovative Cancer Science, 12-15 June 2023, Torino, Italy, FEBS PRESS, 2023, pp. 1 - 597 (atti di: EACR 2023: Innovative Cancer Science, Torino, Italy, 12-15 June 2023) [Poster]
Myers, S. H.; Poppi, L.; Rinaldi, F.; Veronesi, M.; Ciamarone, A.; Previtali, V.; Bagnolini, G.; Schipani, F.; Ortega Martínez, J. A.; Girotto, S.; Di Stefano, G.; Farabegoli, F.; Walsh, N.; De Franco, F.; Roberti, M.; Cavalli, A., An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2023, 265, Article number: 116114 , pp. 1 - 20 [Scientific article]Open Access
Rossi, Valentina; Govoni, Marzia; Di Stefano, Giuseppina, Lactate Can Modulate the Antineoplastic Effects of Doxorubicin and Relieve the Drug's Oxidative Damage on Cardiomyocytes, «CANCERS», 2023, 15, pp. 3728 - 3747 [Scientific article]Open Access
Valentina Rossi; Marzia Govoni; Giuseppina Di Stefano, Lactate preserves genome integrity and extends proliferative potential in cancer cells, in: EACR 2023: Innovative Cancer Science, 12-15 June 2023, Torino, Italy, FEBS PRESS, 2023, pp. 1 - 597 (atti di: EACR 2023: Innovative Cancer Science, Torino, Italy, 12-15 June 2023) [Poster]
Previtali V.; Myers S.H.; Poppi L.; Wynne K.; Casamassima I.; Girotto S.; Di Stefano G.; Farabegoli F.; Roberti M.; Oliviero G.; Cavalli A., Preomic profile of BxPC-3 cells after treatment with BRC4, «JOURNAL OF PROTEOMICS», 2023, 288, Article number: 104983 , pp. 1 - 11 [Scientific article]Open Access
Viola Previtali, Samuel H. Myers, Laura Poppi, Kieran Wynne, Irene Casamassima Stefania Girotto, Giuseppina Di Stefano, Fulvia Farabegoli, Marinella Roberti, Giorgio Oliviero, Andrea Cavalli, Proteomic profile of BxPC-3 cells after treatment with BRC4, «JOURNAL OF PROTEOMICS», 2023, 288, pp. 1 - 11 [Scientific article]
Iacovino, L. G.; Rossi, M.; Di Stefano, G.; Rossi, V.; Binda, C.; Brigotti, M.; Tomaselli, F.; Pasti, A. P.; Dal Piaz, F.; Cerini, S.; Hochkoeppler, A., Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme, «BIOCHIMIE», 2022, 199, pp. 23 - 35 [Scientific article]Open Access
Pasti A.P.; Rossi V.; Di Stefano G.; Brigotti M.; Hochkoeppler A., Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme, «BIOSCIENCE REPORTS», 2022, 42, Article number: BSR20212654 , pp. 1 - 19 [Scientific article]Open Access
Samuel Harry Myers , Viola Previtali, Laura Poppi, Francesco Rinaldi, Fabrizio Schipani, Jose Antonio Ortega, Francesca De Franco, Marina Veronesi, Roberto Pellicciari, Marinella Roberti, Stefania Girotto, Giuseppina Di Stefano, Andrea Cavalli, Identification and subsequent development of RAD51-BRCA2 disruptors through a fragment-based approach, in: ACS Spring 2022, 2022, pp. 1 - 1 (atti di: ACS Spring 2022, San Diego Convention Center, Room 16A, 20/03/2022) [Abstract]
Previtali V., Myers S. H., Bagnolini G., Poppi L., Rinaldi F., Schipani F., Ortega J. A., De Franco F., Pellicciari R., Girotto S., Oliviero G., Walsh N., Valenti G., Tirelli N., Di Stefano G., Roberti M., Cavalli A., Insights into the activity of ARN24089, a new RAD51-BRCA2 disruptor that inhibits homologous recombination and achieves synthetic lethality in pancreatic cancer, in: ACS Spring 2022, 2022, pp. 1 - 1 (atti di: ACS Spring 2022, San Diego Convention Center, Room 16A, 20/03/2023) [Abstract]
Rossi V.; Govoni M.; Farabegoli F.; Di Stefano G., Lactate is a potential promoter of tamoxifen resistance in MCF7 cells, «BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS», 2022, 1866, Article number: 130185 , pp. 1 - 11 [Scientific article]Open Access
