Francesca Sacchi

Dottoranda del Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), lavoro presso il Centro di Ricerca Biomedica Applicata (CRBA) e l'Istituto Nazionale Biostrutture e Biosistemi (INBB), sotto la guida del Prof. Gabriele Matteo D'Uva. La mia attività di ricerca è incentrata sullo studio dei meccanismi molecolari alla base di proliferazione e differenziamento nelle cellule di carcinoma mammario, e sullo sviluppo di strategie innovative per la rigenerazione del tessuto cardiaco a seguito di infarto del miocardio. 

Esperienza di ricerca

2024: Visiting PhD student presso Amsterdam University Medical Center, Amsterdam, Paesi Bassi, sotto la guida della Prof. Monika Gladka.

2021-oggi: Titolare di un assegno di ricerca erogato grazie ad una collaborazione tra Istituto Nazionale Biostrutture e Biosistemi (INBB) e Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), sostenuto da finanziamenti della Fondazione AIRC per la Ricerca sul Cancro, sotto la guida del Prof. Gabriele D'Uva.

Formazione

Dopo la laurea triennale (nel 2018, presso l'Università degli Studi di Milano) e magistrale (nel 2020, presso l'Università degli Studi di Milano-Bicocca) in Biotecnologie Mediche, attualmente sono iscritta al XXXVII ciclo del Corso di Dottorato in Scienze Chirurgiche e Tecnologie Innovative dell'Università di Bologna.

Attività scientifica

Pubblicazioni

• Bongiovanni, C.; Bueno-Levy, H; Posadas Pena, D.; Del Bono, I.; Miano, C.; Boriati, S.; Da Pra, S.; Sacchi, F.; Redaelli, S.; Bergen, M.; Roma niello, D.; Pontis, F.; Tassinari, R.; Keller, L.; Petraroia, I.; Mazzeschi, M.; Lauriola, M.; Ventura, C.; Heermann, S.; Weidinger, G.; Tzahor, E.; D’Uva, G. BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice. Cell Reports 28.05.2024
• Pianca, N.*; Sacchi, F.*, Baruch Umansky, K.; Chirivì, M.; Iommarini, L.; Da Pra, S., Papa, V.; Bongiovanni, C.; Miano, C., Pontis, F.; Braga, L.; Tassinari, R., Pantano, E., Patnala, R.S.; Mazzeschi, M.; Cenacchi, G.; Porcelli, A.M.; Lauriola, M.; Ventura, C., Giacca, M.; Rizzi, R.; Tzahor, E.; D’Uva, G. Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration. Nature Cardiovascular Research 23.06.2022 *Equal contribution
• Miano, C., Romaniello, D., Mazzeschi, M., Morselli, A., Da Pra, S., Sacchi, F., Bongiovanni, C., Sgarzi, M., Pantano, E., Lauriola, M. and D’Uva, G. Neuregulin 4 Boosts the Efficacy of Anti-ERBB2 Neutralizing Antibodies. Frontiers in Oncology 18.05.2022
• Morelli, M.B.*, Bongiovanni, C.*, Da Pra, S.*, Miano, C.*, Sacchi, F.*, Lauriola, M. and D’Uva, G. Cardiotoxicity of anticancer drugs: molecular mechanisms and strategies for cardioprotection. Frontiers in Cardiovascular Medicine 15.04.2022 *Equal contribution
• Miano, C., Morselli, A., Pontis, F., Bongiovanni, C., Sacchi, F., Da Pra, S., Romaniello, D., Tassinari, R., Sgarzi, M., Pantano, E., Ventura, C., Lauriola, M. and D’Uva, G. NRG1/ERBB3/ERBB2 Axis Triggers Anchorage-Independent Growth of Basal-like/Triple-Negative Breast Cancer Cells. Cancers 22.03.2022
• Bongiovanni, C.; Sacchi, F.; Da Pra, S.; Pantano, E.; Miano, C.; Morelli, M.B.; D’Uva, G. Reawakening the intrinsic cardiac regenerative potential: molecular strategies to boost dedifferentiation and proliferation of endogenous cardiomyocytes. Frontiers in Cardiovascular Medicine 08.10.2021
• Monti, P.; Iodice, S.; Tarantini, L.; Sacchi, F.; Ferrari, L.; Ruscica, M.; Vigna, L.; Pesatori, A.C.; Bollati, V. Effects of PM exposure on the methylation of clock genes in a population of subjects with overweight or obesity. International Journal of Environmental Research and Public Health 27.01.2021

Partecipazione con abstract e poster a congressi

• Dissecting the role of corticosteroid receptors in cardiomyocyte proliferative and regenerative ability. F. Sacchi, N. Pianca, S. Da Pra, C. Bongiovanni, C. Miano, I. Del Bono, S. Boriati, F. Pontis, R. Tassinari, C. Ventura, G. D’Uva. ABCD National PhD Meeting, Bologna, Italy. 25-27/03/2024 - First author and poster presenter
• Exploiting glucocorticoid receptor antagonization to enhance NRG1-induced mitogenic activity: a promising strategy for cardiac regeneration. S. Da Pra, S. Boriati, C. Miano, F. Sacchi, C. Bongiovanni, I. Del Bono, A. Aharonov, N. Pianca, G. Petrocelli, C. Manetti, R. Tassinari, C. Ventura, S. Canaider, M. Lauriola, E. Tzahor, G. D’Uva. ABCD National PhD Meeting, Bologna, Italy. 25-27/03/2024– Winner of the poster session
• BMP7 promotes cardiomyocyte regeneration. C. Bongiovanni, H. Bueno-Levy, D. Posadas Pena, I. Del Bono, C. Miano, S. Boriati, S. Da Pra, F. Sacchi, S. Redaelli, M. Bergen, D. Romaniello, F. Pontis, M. Mazzeschi, I. Petraroia, R. Tassinari, L. Kellerer, M. Lauriola, C. Ventura, S. Heermann, G. Weidinger, E. Tzahor, G. D’Uva. ABCD National PhD Meeting, Bologna, Italy. 25-27/03/2024– Winner of the honorable mention for the poster session
• The role of physiological corticosteroids in cardiac regenerative ability. F. Sacchi, N. Pianca, S. Da Pra, C. Miano, C. Bongiovanni, I. Del Bono, S. Boriati, K. Baruch Umansky, M. Chirivì, F. Pontis, R. Tassinari, R. Rizzi, E. Tzahor, C. Ventura, G. D’Uva. Organ transplantation from DCD and the management of multiple organs failure including regenerative medicine, Bologna, Italy. 1-2/12/2023 - First author and poster presenter
• Glucocorticoid Receptor antagonization boosts NRG1 mitogenic activity: implications for cardiac regenerative therapies. S. Da Pra, S. Boriati, C. Miano, F. Sacchi, C. Bongiovanni, I. Del Bono, A. Aharonov, N. Pianca, G. Petrocelli, C. Manetti, R. Tassinari, C. Ventura, S. Canaider, M. Lauriola, E. Tzahor, G. D’Uva. Organ transplantation from DCD and the management of multiple organs failure including regenerative medicine, Bologna, Italy. 1-2/12/2023
• MOLECULAR STRATEGIES TO MODULATE CELL DIFFERENTIATION AND PROLIFERATION: The role of physiological glucocorticoids in cardiomyocyte regeneration. F. Sacchi, N. Pianca, S. Da Pra, C. Bongiovanni, C. Miano, I. Del Bono, F. Pontis, S. Penazza, R. Tassinari, C. Ventura, G. D’Uva. "LEARN & share" Meeting of PhD students of the Department of Medical and Surgical Sciences of Bologna University, Bologna, Italy. 25-26/09/2023 - First author and poster presenter. Winner of the poster session
• Glucocorticoids intercept NRG1/ERBB2 signalling: implications for cardiac regenerative strategies. S. Da Pra, S. Boriati, C. Miano, F. Sacchi, C. Bongiovanni, I. Del Bono, A. Aharonov, N. Pianca, C. Manetti, R. Tassinari, G. Petrocelli, C. Ventura, S. Canaider, M. Lauriola, E. Tzahor, G. D’Uva. "LEARN & share" Meeting of PhD students of the Department of Medical and Surgical Sciences of Bologna University, Bologna, Italy. 25-26/09/2023
• Dual role of corticosteroids in cardiomyocyte proliferative and regenerative ability. F. Sacchi, N. Pianca, S. Da Pra, C. Bongiovanni, C. Miano, I. Del Bono, F. Pontis, S. Penazza, R. Tassinari, C. Ventura, G. D’Uva. 37th Annual Meeting of the International Society for Heart Research-European Section, Porto, Portugal. 10-13/07/2023 - First author and poster presenter. Travel grant to the first author funded by ICGEB (International Centre for Genetic Engineering and Biotechnology)
• Glucocorticoids suppress cardiomyocyte proliferation induced by pro-regenerative growth factors by intercepting MAPK signalling. S. Da Pra, S. Boriati, C. Miano, F. Sacchi, C. Bongiovanni, I. Del Bono, A. Aharonov, N. Pianca, G. Petrocelli, R. Tassinari, C. Ventura, S. Canaider, M. Lauriola, E. Tzahor, G. D’Uva. 37th Annual Meeting of the International Society for Heart Research-European Section, Porto, Portugal. 10-13/07/2023 - Selected for oral presentation by the first author
• The decline of specific growth factor levels during early postnatal development contributes to the loss of mammalian cardiomyocyte regenerative potential. C. Bongiovanni, H. Bueno-Levy, D. Posadas Pena, S. Redaelli, M. Bergen, I. Del Bono, S. Da Pra, C. Miano, F. Sacchi, D. Romaniello, M. Mazzeschi, R. Tassinari, M. Lauriola, C. Ventura, S. Heermann, G. Weidinger, E. Tzahor G. D’Uva. 37^th Annual Meeting of the International Society for Heart Research-European Section, Porto, Portugal. 10-13/07/2023 - Travel grant to the first author funded by ICGEB (International Centre for Genetic Engineering and Biotechnology)
• Detection of new growth factors boosting cardiomyocyte proliferation. C. Bongiovanni, H. Bueno-Levy, D. Posadas Pena, S. Redaelli, M. Bergen, S. Da Pra, I. Del Bono, C. Miano, F. Sacchi, F. Pontis, M. Mazzeschi, I. Petraroia, R. Tassinari, M. Lauriola, C. Ventura, S. Heermann, G. Weidinger, E. Tzahor, G. D’Uva. 14^th National Congress of the National institute of Biostructures and Biosystems, Rome, Italy, 17-18/11/2022 - Winner of the Poster Session
• Dissecting the role of ERBB Receptors in basal-like breast cancer. C. Miano, A. Morselli, F. Sacchi, S.Da Pra, C. Bongiovanni, I. Del Bono, L. Salis, R. Tassinari, D. Romaniello, M. Sgarzi, C. Ventura, M. Lauriola, G. D’Uva. 14^th National Congress of the National institute of Biostructures and Biosystems, Rome, Italy, 17-18/11/2022
• Identification of novel growth factors triggering cardiomyocyte proliferation and cardiac regeneration. C. Bongiovanni, H. Bueno-Levy, S. Da Pra, I. Del Bono, C. Miano, F. Sacchi, F. Pontis, M. Mazzeschi, I. Petraroia, R. Tassinari, M. Lauriola, C. Ventura, E. Tzahor, G. D’Uva. "LEARN & share" Meeting of PhD students of the Department of Experimental, Diagnostic and Specialty Medicine of Bologna University, Bologna, Italy, 29-30/09/2022 - Winner of the Poster Session
• Identification of novel growth factors for cardiac regeneration. C. Bongiovanni, H. Bueno-Levy, S. Da Pra, I. Del Bono, C. Miano, F. Sacchi, F. Pontis, M. Mazzeschi, I. Petraroia, R. Tassinari, M. Lauriola, C. Ventura, E. Tzahor, G. D’Uva; ERA-Net on Cardiovascular Diseases (ERA-CVD), Riga, Latvia, 19-20/09/2022
• Neuregulin/ErbB signalling in breast cancer cell differentiation and growth. C. Miano, C. Bongiovanni, F. Sacchi, S. Da Pra, F. Pontis, M. Sgarzi, M. Lauriola, G. D’Uva; Cancer Italian Society (SIC), 27/10/2021 – Selected for oral presentation
• Antagonization of glucocorticoid receptor facilitates heart regeneration by promoting cardiac muscle cell dedifferentiation and proliferation. F. Sacchi, N. Pianca, C. Bongiovanni, K. Baruch Umansky, M. Chirivì, L. Iommarini, S. Da Pra, F. Pontis, V. Papa, L. Braga, R.S. Patnala, R. Tassinari, M. Mazzeschi, G. Cenacchi, C. Ventura, A.M. Porcelli, M. Lauriola, M. Giacca, R. Rizzi, E. Tzahor and G. D’Uva; 74^th National Congress of the Italian Society of Anatomy and Histology, Bologna, Italy, 24-25/09/2021 - Selected for oral presentation and published in Italian Journal of Anatomy and Embryology (IJAE)
• Glucocorticoid receptor signalling restrains cardiomyocyte proliferation and cardiac regeneration by modulating the energetic metabolism. N. Pianca, K. Baruch Umansky, M. Chirivì, L. Iommarini, F. Pontis, V. Papa, L. Braga, C. Bongiovanni, F. Sacchi, S. Da Pra, R.S. Patnala, M. Mazzeschi, G. Cenacchi, A.M. Porcelli, M. Lauriola, M. Giacca, R. Rizzi, E. Tzahor and G. D’Uva, 36^th Annual Meeting of the International Society for Heart Research-European Section, 29/06 - 01/07/2021 - Selected for oral presentation and published in Frontiers in Vascular Physiology
• A bone morphogenetic ligand triggers mammalian cardiac regeneration by enhancing cardiomyocyte proliferation. C. Bongiovanni, H. Bueno-Levy, F. Pontis, S. Da Pra, M. Mazzeschi, I. Petraroia, R. Tassinari, F. Sacchi, M. Lauriola, C. Ventura, E. Tzahor and G. D’Uva, 36^th Annual Meeting of the International Society for Heart Research-European Section, 29/06 - 01/07/2021 - Selected for oral presentation and published in Frontiers in Vascular Physiology

Diffusione mediatica delle pubblicazioni

• Nature Reviews Cardiology: Glucocorticoid receptor inhibition promotes cardiac repair after MI, 13/07/2022
• Spamchronicles: Researchers unveil a key gene in heart repair after a heart attack, 02/07/2022
• Nature Reviews Cardiology: Glucocorticoid receptor inhibition promotes cardiac repair after MI, 13/07/2022
• Medicina y Salud Publica: Investigadores revelan un gen clave en la reparación del corazón tras un infarto, 01/07/2022
• TGR Emilia Romagna 01/07/2022
• La Repubblica: Ormoni (ma non solo), così si spera di rigenerare il cuore dopo l’infarto, 27/06/2022
• TGR Puglia 26/06/2022
• La Repubblica (Bologna): Ateneo di Bologna, la ricerca sull'infarto: scoperto un ormone chiave per riparare il cuore, 24/06/2022
• Sky TG24: Infarto cardiaco, individuato ormone chiave per riparare il cuore, 24/06/2022
• Il resto del Carlino: Infarto, la scoperta dell'Unibo: ecco l'ormone che può riparare il cuore, 23/06/2022