- Docente: Walter Cabri
- Credits: 6
- SSD: CHIM/06
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Chemistry (cod. 9072)
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from Sep 25, 2024 to Jan 10, 2025
Learning outcomes
At the end of the course, the student will be able to evaluate various hypotheses for the total synthesis of active pharmaceutical ingredients (APIs) suitable for the preparation on a large scale, based on economic criteria and normative restrictions. The student will acquire knowledge about the solvents and reagents more used for large scale productions, on the analytical investigations required for market approval, and on regulatory issues related to the scaled-up processes. The students will also acquire the critical capacity to evaluate, modify, and propose synthetic methodologies suitable for large-scale preparation of a new organic molecule.
Course contents
1. Drug Discovery e Molecular Complexity.
2. Synthetic methodologies trends in the Pharma Industry.
3. Intellectual Property.
4. Solid State.
5. Analytical Challanges in drug development. Genotoxic impurities, elemental impurities, nitrosamines etc.
6. Green Technologies, catalysis & flow chemistry.
7. Case histories of several drugs development form bench to market.
Readings/Bibliography
“From Bench to Market. The Evolution of Chemical Synthesis from Discovery to Industrial Production.”; Oxford University Press: Oxford, 2000.
Specific publications will be given to the students.
Teaching methods
Frontal course with slides projected in class and commented with the help of interactive screens or blackboard.
Assessment methods
Oral examinations
Teaching tools
Copies of the slides in pdf will be provided to the students.
It is useful to remind that students cannot share or publish the slides of the course in full or in part.
Office hours
See the website of Walter Cabri