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93307 - Diagnostic Molecular Pathology

Academic Year 2024/2025

                
                        Docente:
                        Michelangelo Fiorentino
                    
                        Credits:
                        6
                    
                        SSD:
                        MED/08
                    
                        Language:
                        Italian
                    
                        Moduli:
                        
                            Michelangelo Fiorentino
                            (Modulo 1)
                        
                            Claudio Agostinelli
                            (Modulo 2)
                        
                        Teaching Mode:
                        Traditional lectures
                        
                                    Traditional lectures (Modulo 1)
                                
                                    Traditional lectures (Modulo 2)
                                
                            Campus:
                            Bologna
                        
                            Corso:
                            First cycle degree programme (L) in
                            Biotechnology (cod. 8005)

                            Teaching resources on Virtuale
                        
                                        Course Timetable
                                    
from Mar 04, 2025 to May 14, 2025

                                        Course Timetable
                                    
from Mar 24, 2025 to May 28, 2025

Learning outcomes

The course aims to provide the basic elements of the molecular bases and of the main diagnostic molecular tests in human solid tumors. At the end of the course the student will be confident of the basic knowledge on the epidemiology, the histological diagnosis and the interpretation of molecular pathology tests.

Course contents

The course aims to provide the students with the basic elements of diagnostic molecular pathology, with particular focus on solid and hematologic tumors.

At the end of the course the student will learn the molecular bases of the main human tumors and the theory and the interpretation of the main techniques of diagnostic molecular pathology.

Program/Contents

Basic histopathology.
Techniques in histopathology.
Fundamentals of molecular diagnostics: in vitro techniques.
Fundamentals of molecular diagnostics: in situ techniques.
Immunohistochemistry.
Fluorescent and chromogenic in situ hibridization.
PCR/Real time PCR
Direct sequencing
NGS sequencing
Molecular tests predictive of response in personalized oncological medicine.
Focus on solid tumors: prostate cancer.
Focus on solid tumors :colo-rectal cancer.
Focus on solid tumors: breast cancer.
Focus on solid tumors: lung cancer.
Focus on solid tumors: kidney cancer.
Focus on solid tumors: melanoma.
Focus on solid tumors: liver cancer.
Focus on solid tumors: bladder cancer.
Focus on tumors: leukemia and lymphomas

Readings/Bibliography

Class presentations are available on Virtuale.

Teaching methods

Class presentations.

Attendance to learning activities is mandatory; the minimum attendance requirement to be admitted to the final exam is 60% of lessons.

Assessment methods

The final exam consists of a written test with 30 multiple choice questions on the matter of the presentations.
For each question, the student receives a vote. The weighted result based on the median performance of the other students and the standard deviation is expressed in 30/30.

Teaching tools

Discussion on digitalized histological slides

Office hours

See the website of Michelangelo Fiorentino

See the website of Claudio Agostinelli