- Docente: Stefano Severi
- Credits: 9
- SSD: ING-INF/06
- Language: Italian
- Moduli: Stefano Severi (Modulo 1) Stefano Severi (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Cesena
- Corso: Second cycle degree programme (LM) in Biomedical Engineering (cod. 8198)
Learning outcomes
The course introduces students to the main methods and technologies for the analysis of biological processes on molecular and cellular scales. The student learns to develop computer models for numerical simulations and improves its attitude to abstract the experimental observation. Case studies concern: the enzymatic kinetic, competitive and cooperative molecular interactions, cellular excitability. The experimental methods used in cellular electrophysiology are also reviewed. The student acquires specific knowledge on physio-pathological mechanisms of cardiac electrophysiology and becomes able to analyse them through a multiscale computational approach.
Course contents
Cellular constituent structure and functions
Molecular reaction
Metabolic network
Gene regulation
Syntetic biology
Elements of dynamic system theory
Elements of bifurcation theory
Chaos and complexity
Intracellular calcium kinetics
Ion channels
Cellular excitability: nervous and cardiac cellules
Molecular mechanics at the base of information transmission
Readings/Bibliography
Books used to prepare lectures
J. Keener and J. Sneyd, “Mathematical physiology”
Z. Sballasi, J. Stelling, V. Periwal, "System Modeling in
cellular Biology"
K.E. Drexler, “Nanosystems”
E. A. Rietman, “Molecular Engineering of Nanosystems”
M. Scherge and S. Gorb, “Biological Micro- and
Nano-tribology”
M. Heller and A. Guttman, “Integrated microfabricated
biodevices”
J. M. Bower and H. Bolouri, “Computational modelling of genetic and
biochemical networks”
C. Branden and J. Tooze, “Introduzione alla struttura delle
proteine”
D. Voet, "Fundamentals of Biochemistry"
Hille, “Ion Channels of Excitable Membranes”
Teaching methods
Lectures. Pratical in computational biological laboratory (8 hours at least) ; Pratical in Molecular and cellular Engineering Laboratory.
Assessment methods
Written test and Interview at the end of the course.
Teaching tools
Molecular and Cellular Engineering Lab "Silvio Cavalcanti".
Biological Computational Lab.
Office hours
See the website of Stefano Severi