- Docente: Brunella Del Re
- Credits: 4
- SSD: BIO/18
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Molecular and cellular biology (cod. 8021)
Learning outcomes
The aim of this course is to provide students with a through knowledge of immunology from the viewpoints of genetics by studying structure, function and evolution of genes involved in immune response.
Course contents
Methodological aspects of immunogenetics: classical genetics, molecular genetics, genomics. Evolution of the innate immune system: Toll-like receptors, complement system, cytokines. Evolution of the adaptive immune response. Immunoglobulin genes: recombination between gene segments, allelic exclusion, class switching, receptor editing, somatic ipermutation, gene expression regulation. T-cell receptor genes: recombination between gene segments, gene expression regulation. The major histocompatibility locus: structure, function, polymorphisms. Associations between HLA and disease. Genetc aspects of immunological diseases :inherited mmunodeficiency (SCID), acquired mmunodeficiency (AIDS), hypersensitivity, autoimmunity, allergy. Genetics of susceptibility or resistance to infectious disease.
Readings/Bibliography
Assessment methods
Written test and oral examination
Links to further information
http://www.unibo.it/SitoWebDocente/default.htm?upn=brunella.delre%40unibo.it&TabControl1=TabAvvisi
Office hours
See the website of Brunella Del Re