B5461 - MICROBIAL BIOTECHNOLOGIES FOR THE CIRCULAR PRODUCTION OF MOLECULES OF INDUSTRIAL INTEREST FOR THE PHARMA-FOOD SECTOR AND AS INNOVATIVE BIOMATERIALS

Conoscenze e abilità da conseguire

The student will learn: - the main principles and approaches of microbial biotechnologies, including the management and control of the biological resources and the setup of tailored fermentation processes for the production of industrial products; - the main multiomics technologies (eg. metagenomics, metaproteomic and metabolomics) applied to the biodiscovery and screening of new bioresources and the regulatory aspects concerning the IPR protection; - concrete examples of circular process for the valorization of industrial side streams for the production of: platform chemicals as VFA, pharmaceuticals/nutraceuticals, bioplastics and bacterial cellulose;

Contenuti

1. Hints on basic aspects on microbiology, microbial ecology and microbial biotechnology for industrial applications: diversity of the microbial life, genomic, cloning and expression systems for biotechnological applications, fermentation approaches and platforms;
2. Approaches and technologies for the discovery of new microbial bioresources of industrial interest: search, isolation, characterization and functional screening of new bioresources;
3. Regulatory aspects and limits for the usage and exploitation of natural bioresources, valorization of the intellectual property in the context of the Nagoya protocol;
4. Design and implementation of circular process for the valorization of industrial side streams (eg. lignocellulosic biomass and agri-food waste/residues) for the production of molecules of industrial interest (eg. bioactive small molecules as polyketides and non-ribosomal peptides; volatile fatty acids; microbial bioplastics, bacterial cellulose and dyes, among others)

Testi/Bibliografia

• Metagenomics. 1st Edition Perspectives, Methods, and Applications Muniyandi Nagarajan Academic Press Inc.(London) Ltd
• R in Action. Third Edition. Robert I. Kabacoff. Manning Publications
• Brock Biology of Microorganisms. 16th Edition. Michael M. Madigan, Kelly S. Bender, Daniel Buckley, W. Matthew Sattley, David A. Stahl Pearson
• Fermentation Microbiology and Biotechnology. Fourth Edition. E. M. T. El-Mansi, Jens Nielsen, David Mousdale, Ross P. Carlson. CRC Press
• Industrial Microbiology, an introduction. Michael J. Waites, Neil L. Morgan, John S. Rockey and Gary Higton. Blackwell Science.

Metodi didattici

Lezioni frontali

Modalità di verifica e valutazione dell'apprendimento

Esame orale

Strumenti a supporto della didattica

lavagna e proiettore

Orario di ricevimento

Consulta il sito web di Marco Candela