99582 - COSMETIC FORMULATIONS ANALYSIS AND QUALITY CONTROL.

Conoscenze e abilità da conseguire

Lo studente, in seguito alla frequenza e al superamento del corso “Cosmetic formulations analysis and quality control” -acquisisce le conoscenze relative all’applicazione pratica dei principali metodi strumentali (HPLC, GC, GC-MS, HPLC-MS, fluorimetria, HPLC-DAD, UV-Vis, etc.) per l’analisi di formulazioni cosmetiche, appartenenti alle categorie indicate nella legislazione cosmetica europea, relativamente alla verifiche dei contenuti di ingredienti permessi in determinati limiti e condizioni secondo legislazione vigente, alla verifica della stabilità e al controllo di qualità, comprendendo anche la ricerca di sostanze vietate per legge; -è in grado di impostare adeguatamente le procedure preliminari di pre-trattamento del campione, in base alla tipologia del prodotto cosmetico finito, e di scegliere e convalidare l’idonea procedura analitica; -è in grado di applicare le conoscenze acquisite a problemi reali ed a nuove problematiche correlate al settore analitico cosmetico.

Contenuti

Analytical advanced methodologies (HPLC, GC, HPLC-MS, fluorometry, HPLC-DAD, UV-VIS, etc.) and sample preparation for the analysis of cosmetic formulations belonging to the categories reported in the European legislation ((body and hair wash, toothpaste, emulsions hydro and lipo gels) in view of quality control and stability studies. Validation of the methods and determination of validation parameters.

Laboratory practice:

1. Solubility assay and UV, IR and fluorescence spectra registration, determination of polarimetry constant (quinine, benzoic acid, triclosan, chlorocresol, camphor, menthol)

   Cosmetic products in solution

2. Determination of Quinine in a liquid hair cosmetic product via L/L extraction and UV spectroscopy
3. Determination of benzoic acid in a liquid hair cosmetic product via L/L extraction and titration
4. Direct Determination of Quinine in a liquid hair cosmetic product by fluorescence spectroscopy
5. Determination of Thioglycolic acid in a hair permanent cosmetic product by UV spectroscopy (redox method with Fe3+ and phenanthroline)
6. Determination of Thioglycolic acid in a hair permanent cosmetic product by HPLC-UV, via pre-column derivatization with ethacrynic acid

   Cosmetic products in gel

7. Determination of Triclosan in toothpaste and mouthwash by HPLC-UVDAD
8. Gas-chromatographic (GC-FID) determination of menthol and camphor in a cosmetic gel

   Cosmetic product in cream

9. Determination of Chlorocresol in a 0/W cream by HPLC-UVDAD
10. Determination of Chlorocresol in a O/W cream by Solid Phase Extraction and GC-FID

 

Testi/Bibliografia

Amparo Salvador,and Alberto Chisvert 'Analysis of Cosmetic products' second edition 2018, Elsevier

Metodi didattici

As concerns the teaching methods of this course unit, all students must attend Module 1, 2 [https://www.unibo.it/en/services-and-opportunities/health-and-assistance/health-and-safety/online-course-on-health-and-safety-in-study-and-internship-areas] online, while Module 3 on health and safety is to be attended in class or on Microsoft Teams according to the modality chosen by the teacher. Information about Module 3 attendance schedule is available on the website of your degree programme.

Frontal lessons, videos and lab practise

Modalità di verifica e valutazione dell'apprendimento

Lab exam and oral discussion

Strumenti a supporto della didattica

Slides and videos

Orario di ricevimento

Consulta il sito web di Vincenza Andrisano