B7295 - Advanced Functional Genetics in Model Organisms

Learning outcomes

The overall aim of the course is to provide a comprehensive understanding of the use of model organisms in functional genetic research. Students will gain knowledge and skills on how to design experiments in model organisms to address questions on fundamental biological and pathological mechanisms. Students will learn how to interpret data and infer the underlining genetic molecular mechanisms. Lectures will consist of a combination of regular lessons and seminars

Course contents

During the course, students will explore the diversity of model organisms, including Yeasts (S. cerevisiae), Protists (Dictyostelium), Algae (Chlamydomonas), Nematodes (C. elegans), fruit flies (Drosophila), Fish (D. rerio), Amphibians (Xenopus), Birds (G. gallus), Mammals (M. musculus) and Plants (A. thaliana).

Throughout the course, we will cover several key topics. We'll begin with an introduction to model organisms, including definitions, a historical overview, and criteria for selecting model organisms. Students will learn how model organisms are used in genetic studies and genome editing, gaining insights into development and differentiation provided by these organisms. We will investigate various physiological processes and behaviors, and cover how model organisms help us understand human diseases. We’ll also discuss the ethical issues and regulations involved in the use of model organisms. For each of these organisms, we will cover their life cycle, biology, and genetics, characteristics that make them valuable as model organisms, available genetic and molecular tools, and their main applications in contemporary research.

Readings/Bibliography

A list of recommended research and review articles will be provided during the course.

Teaching methods

The course will employ a mix of frontal teaching and active student participation through the preparation and presentation of seminars. Frontal teaching will provide foundational knowledge, while seminars will offer opportunities for in-depth exploration of specific topics.

Assessment methods

Assessment will be based on the quality and depth of the seminar presentation given by each student during the course, as well as a write examination. The write exam will consist of questions related to the course content, evaluating the student's understanding and ability to apply their knowledge.

Teaching tools

The course will be conducted in classrooms equipped with computer projection systems. Frontal teaching and seminars will utilize PowerPoint presentations, and all supporting materials (articles, reviews, bibliographies, and websites) will be made available to students at the end of each session.

Office hours

See the website of Nicola Facchinello