- Docente: Olivia Manfrini
- Credits: 1
- SSD: MED/11
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 5904)
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from May 13, 2025 to May 27, 2025
Course contents
EPIDEMIOLOGY OF IHD. Incidence and geographical distribution of IHD in both sex.
SEX AND IHD RISK PROFILE. Traditional CV risk factors (HTN, DM, SMK, Hyperchol). Non-traditional CV risk factors (obesity, psychological disorders, social differences, marital status). Autoimmune diseases & inflammation. Female specific RF (estrogens, HRT, polycystic ovary syndrome, disorders of pregnancy, cancer). Transgender.
SEX DIFFERENCES IN THE ANATOMY & PHYSIOLOGY OF THE CORONARY CIRCULATION Anatomic features. Myocardial perfusion and coronary flow reserveAutonomic function.
SEX DIFFERENCES IN EARLY CORONARY ATHEROSCLEROSIS. Endothelial dysfunctionAtheroma burdenGenetic predisposition
STRENGTH AND WEAKNESS OF DIAGNOSTIC TESTS IN WOMEN. Markers of inflammation, necrosis and ventricular dysfunction. ECG and other non-invasive tests. Coronary angiography and invasive tests.
SEX DIFFERENCES IN ACUTE CORONARY SYNDROMES
PATHOPHYSIOLOGY. Microvascular dysfunction. Coronary Spasm. Plaque erosion / rupture /calcified nodules. Thrombus burden and composition in women with ACS. Coronary dissection.
PRESENTATION. Delay to hospital arrival. Symptoms. Age and comorbidity burden. ECG-findings (STEMI/NSTACS). Coronary-findings (Obstructive CAD/MINOCA).
MANAGEMENT STRATEGIES. Are women still less treated? Is the so call optimal-treatment really the optimal-treatment-for-women?Pharmacological Therapy (Including response to prolonged antithrombotic therapy after ACS). Invasive treatment (PCI & CABG).Long-term outcomes in older adults undergoing invasive treatment for NSTE-ACS. Cardiogenic shock complicating ACS
OUTCOME. STEMI. NSTE-ACS. ACS with obstructive CAD vs MINOCA. Patients without risk factors (SMuRFS)
SEX DIFFERENCES IN CHRONIC CORONARY SYNDROMES. Symptoms. Age and comorbidity burden. Obstructive CAD vs INOCA. Outcome
Office hours
See the website of Olivia Manfrini