- Docente: Marco Lucarini
- Credits: 8
- SSD: CHIM/06
- Language: Italian
- Moduli: Marco Lucarini (Modulo 1) Andrea Cantelli (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in Pharmaceutical Chemistry and Technology (cod. 5986)
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from Mar 03, 2025 to May 26, 2025
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from Mar 17, 2025 to Apr 08, 2025
Learning outcomes
Aim of the course is to provide the student with the knowledge necessary to identify and characterize an organic compound by usingspectroscopic techniques.
In order to follow profitably the course the student must know the basic principles of organic chemistry as well as of physics.
Course contents
Quantization of the energy levels of atoms and molecules. Absorption of electromagnetic radiations by molecules.
UV and visible spectroscopy. Beer-Lambert law. Electronic transitions and Molecular Orbitals. Absorbing groups: polyenes, aromatic rings, carbonyl compounds. Substituent and solvent effects on electronic transitions. Structural information from UV and visible spectra. Applications.
Linear and circular dichroism: outlines.
Fluorescence spectroscopy. Excited electronic states and Jablonski diagram. Fluorescence and phosphorescence. Applications.
Infrared spectroscopy. Harmonic and anharmonic oscillators. Selection rules for vibrational transitions. Group frequencies and analysis by IR.
Nuclear Magnetic Resonance. Zeeman interaction between nuclear spin and magnetic field. Spin-spin coupling. NMR spectra of AX and AB systems. First order spectra. Chemical shift and chemical structure. Factors determining the magnitude of the spin-spin coupling constants. Interpretation of simple proton NMR spectra.
Carbon-13 NMR spectra. The sensitivity in NMR spectroscopy. Pulsed NMR and Fourier transform. Proton decoupling. Chemical shift of carbons. Applications.
Mass spectrometry. Principles and outlines of instrumentation. Ionisation by electron impact and chemical ionisation. Mass analysers. Molecular ion and isotopomers. Modes of fragmentation. Fragmentation of common functional groups.
Readings/Bibliography
G.F. Pedulli, Metodi Fisici in Chimica Organica, Piccin Editore.
Teaching methods
Lectures and training lessons
Assessment methods
Solution of an exercise consisting in the identification of an unknown substance on the basis of the IR, UV, proton and 13C NMR, and Mass spectra.
Written exam on the theoretical and practical aspects of the various spectroscopic techniques
Teaching tools
PowerPoint slides
Office hours
See the website of Marco Lucarini
See the website of Andrea Cantelli