B2145 - TECNICHE AVANZATE IN SINTESI ORGANICA

Learning outcomes

At the end of the course, the student will acquire in-depth knowledge in the use of advanced technologies in organic synthesis, such as: electrochemical synthesis/catalysis, electrochemical synthesis/catalysis combined with photocatalysis, mechanochemistry, and flow chemistry. The student will also gain experience in heterogeneous chemical catalysis with specific reference to anchoring methodologies of catalytic species on inert matrices. By the end of the course, the student will also possess detailed knowledge of current applications of the advanced techniques discussed in the productive sector.

Course contents

The student that plans to attend the course, in order to get maximum comprehension of the topics of the lessons must be confident with the programmes of the basic organic chemistry with particular concern to the synthesis and functionalization of the main organic functional groups (from alkanes to carboxylic derivates).

The text book “Organic Chemistry” by J. Clayden, N. Greeves, S. Warren is kindly suggested. Moreover, the student should already be practice with common lab glass-ware, with the setting of an organic reaction, monitoring of the process by means of TLC and classic work-up. Finally, the student is supposed to known how to get structural information on a title organic species via NMR-spectroscopy 1H and 13C (The latter part for what it does concern the laboratory section).

1. MechanoChemistry

1.1 Historical background
1.2 Basic principles
1.3 Ball milling apparatus and materials
1.4 Application in Organic Synthesis
1.5 Examples of large-scale productions

2. Electrosynthesis
2.1 Basic principles and historical background
2.2 Electrochemical cells for organic synthesis
2.3 Applications in organic synthesis

3. Visible-light promoted organic synthesis
3.1 Basic principles and historical background
3.2 Photochemical principles applied to organic synthesis
3.3 Photocatalysts
3.4 Examples of light mediated organic synthesis
3.5 Large scale applcations

4. Flow synthetic organic chemistry
4.1 Introduction
4.2 Why running a reaction in flow
4.3 Applications in organic synthesis
4.4 Phtochemistry in flow
4.5 Electrochemistry in Flow
4.6 Scale-up

5. CO₂ as C1-building block in organic synthesis
5.1 Greenhous effect, general consideration on the role of CO₂
5.2 CO₂: chemical properties
5.3 Chemical activation modes of CO₂
5.4. CO₂ in carboxylation processes
5.5 CO₂ in carbonylating processes.

6. Carbo-nanofomrs in organic synthesis
6.1 Zero, mono- and bidimensional ordered forms of carbon species
6.2 Fullerenes and their covalent modifications
6.3 Nanotubes and their covalent modifications
6.4 Graphene and graphene oxides: chemistry and application in organic synthesis
6.5. Use of carbon-based nanomaterials as inert supports

 

Teaching methods

Theoretical lessons (use of black-board, and projection of slides via ppt presentations).

Two-days laboratory course

Assessment methods

The final examination aims to ascertain the student's acquired skills, and consists of an oral examination (45 minutes).

This oral examination begins by discussing a recent publication related to the course contents, provided to the candidate one week before the examination. This will be the intriductive chat to discuss the topics treated during the course.

Teaching tools

Slides will be provided to the students. No comprehensive monographs dealing with all the topics of the course are available in the market.

Course organization: 28 hours theoretical teaching - 8 hours pratical courses.

Office hours

See the website of Marco Bandini