02404 - Haematology

Learning outcomes

At the end of the course the student possesses the knowledge to recognize and interpret the main diseases of the blood and of the hemolymphopoietic system, both neoplastic and non-neoplastic. In particular, the student is able: - to interpret the signs, symptoms and laboratory data that characterize anemia; acute, myeloid and lymphoid leukaemias; chronic myeloproliferative syndromes; lympho-immuno-proliferative syndromes; thrombocytopenia and coagulation disorders; - to know the main modalities of application of autologous and allogeneic stem cell transplantation.

Course contents

Anaemias: classification and differential diagnosis.
Causes of anemia. aplastic anemia, iron-deficient A, megaloblastic A, chronic diseases A. and CRD-associated A, haemolytic A such as G6PD deficiency, autoantibodies, and acquired forrms such as paroxysmal nocturnal hemoglobinuria), Thalassemia and sickle cell anemia.
Chronic myeloproliferative disorders: chronic myeloid leukemia; polycythemia vera, essential thrombocythemia, myeloid metaplasia with myelofibrosis, hypereosinophilic syndrome Acute myeloproliferative disorders: acute myeloid leukemia (FAB-WHO-ICC-ELN classification).
Chronic lymphoproliferative disorders: chronic lymphocytic leukemia, prolymphocytic leukemia, hairy cell leukemia, Sezary syndrome, Hodgkin lymphoma, non-Hodgkin lymphoma. Monoclonal gammapathies: multiple myeloma, Waldestrom's disease, amyloidosis, cryoglobulinemia. Acute lymphoproliferative disorders: acute lymphoblastic leukemia (B,T) (immunological classification, FAB, WHO, ICC, ELN classifications).
Haematological changes in solid tumours. bone marrow insufficiency. Hypercalcemic syndrome. Tumor lysis syndrome. Complications of chemotherapy: nausea and vomiting, skin and mucous membranes, secondary leukemia and second tumours, pulmonary, neurological, cardiological, endocrine.

Bleeding diseases:
-Congenital and acquired thrombocytopenia on an autoimmune basis, from consumption (PTT, CID)
- Coagulation factor deficiency disorders (F vW deficiency disease), Congenital haemophilia A and B and acquired forms. Thrombotic diseases:
- from natural anticoagulant deficiency to acquired forms.

For each pathology examined, the pathophysiological, clinical, diagnostic and therapeutic aspects will be discussed.

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Integrated course of Hematology, Clinical Immunology and Rheumatology

Academic Year 2024-2025
Lecture program of the Hematology course
(Ravenna Campus)
Lesson 1
HEMOPOIESIS AND STEM CELLS
Lesson 2
ERYTHROPOIESIS AND CLASSIFICATION OF ANEMIAS
Lesson 3
MEGALOBLASTIC ANEMIA and APLASTIC ANEMIA
Lesson 4
IRON METABOLISM AND IRON DEFICIENCY ANEMIA
Lesson 5
HEMATOLOGY LABORATORY AND TRANSFUSION OF BLOOD AND BLOOD COMPONENTS IN HEMATOLOGY
Lesson 6
HEMOGLOBINOPATHIES AND THALASSEMIAS (BETA THALEXEMIA MINOR and SICKLE CELL ANEMIA)
Lesson 7
BETA THALASSEMIA MAIOR
Lesson 8
HEMOLYSIS AND HEMOLYTIC ANEMIA
Lesson 9
CLINICAL CASES OF ANEMIA
Lesson 10
ACUTE AND CHRONIC LEUKEMIA: GENERAL CONCEPTS AND ROLE OF MOLECULAR GENETICS AND CYTOMETRIC DIAGNOSTICS Lesson 11
ACUTE MYELOID LEUKEMIA
Lesson 12
ACUTE LYMPHOBLASTIC LEUKEMIA
Lesson 13
CHRONIC MYELOPROLIFERATIVE NEOPLASMS: OVERVIEW AND CHRONIC MYELOID LEUKEMIA
Lesson 14
Ph1-NEGATIVE CHRONIC MYELOPROLIFERATIVE NEOPLASMS Lesson 15
MYELODYSPLASTIC SYNDROMES
Lesson 16
MONOCLONAL GAMMAPATHIES AND IMMUNOPROLIFERATIVE SYNDROMES
Lesson 17
MULTIPLE MYELOMA
Lesson 18
CHRONIC LYMPHATIC LEUKEMIA AND RELATED DISEASES
Lesson 19
NODAL AND EXTRANODAL NON-HODGKIN LYMPHOMAS
Lesson 20
HODGKIN LYMPHOMA
Lesson 21
PLATELET POIESIS AND THROMBOCYTOPENIA
Lesson 22
CLASSIFICATION OF ACQUIRED AND CONGENITAL PLALTELET DISORDERS AND COAGULOPATHIES
Lesson 23
AUTOLOGOUS AND ALLOGENEIC STEM CELL TRANSPLANTATION Lesson 24
CELL THERAPIES AND ASPECTS OF HUMANIZATION OF TREATMENTS IN ONCO-HEMATOLOGY

Readings/Bibliography

- TURA,CAVO, ZINZANI - Malattie del Sangue e degli Organi Emolinfopoietici. I Ed.2020, Pag.656; Esculapio Medicina.
ISBN 978-88-9385-203-6

- Ematologia - Core Curriculum 2/ed. di Castoldi Gianluigi; Editore: McGraw-Hill Italia; Collana: Core Curriculum - Mc Graw
Anno: 2014; Edizione: 2: Pag.: 359
ISBN 978-88-386-3980-7

- Ematologia di Mandelli - a cura di Giuseppe Avvisati. Seconda Edizione. Editore: Piccin Anno: 2019
ISBN 978-8829929603

Teaching methods

The teaching aims to guide the student to learn: the epidemiology, causes, pathogenesis and clinical-therapeutic aspects of the main diseases of the lymphatic and hematopoietic systems, including forms of anemia, leukopenia and thrombocytopenia, neoplasms, and coagulation diseases (venous thrombosis and haemorrhagic diseases) .
- the molecular, pathophysiological and clinical basis of the diagnosis and therapy of the main haemolymphatic diseases
- the clinical-laboratory management of patients with haematological malignancies, in the different clinical phases of the disease and in the different types of tumor.
- the organization of treatment schemes for the various pathological conditions
It also aims to develop knowledge of medical semeiotics in hemolymphopathies and to increase awareness of the biology of blood cells and the mechanisms of genetic and molecular alterations inherent in the neoplastic transformation of hematopoietic tissues.
As secondary objectives, the objective is to develop autonomy in the classification of hematological pathologies and to acquire knowledge on the main target and molecular target therapies in the various hemo-lymphopoietic diseases. Students will be learning the humanization of onco-hematological treatments as an integral part of the correct therapeutic approach of the hematological patient.

Office hours

See the website of Francesco Lanza

See the website of Giovanni Marconi