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91024 - Basis of Clinical Molecular Biology

Academic Year 2024/2025

                
                        Docente:
                        Stefano Iotti
                    
                        Credits:
                        3
                    
                        SSD:
                        BIO/12
                    
                        Language:
                        English
                    
                        Teaching Mode:
                        Traditional lectures
                        
                            Campus:
                            Rimini
                        
                            Corso:
                            Single cycle degree programme (LMCU) in
                            Pharmacy (cod. 9078)

                                Also valid for
                                
                                    Single cycle degree programme (LMCU) in
                                    
                                        Pharmacy (cod. 5987)
                                    
                            Teaching resources on Virtuale
                        
                                    Course Timetable
                                
from Sep 30, 2024 to Dec 10, 2024

Learning outcomes

The student at the end of the course: - knows the biochemical and metabolic processes characteristic of the main organs, with references to the biochemical defects that underlie the corresponding metabolic diseases; - knows the different mechanisms of regulation and the different functionality of metabolic processes in different tissues; - acquires an overall vision of the metabolic homeostasis processes, introducing more advanced concepts such as process integration, control of complex systems and integration between reductionist and holistic approach. - learns the basic knowledge for the understanding of the thermodynamics of dissipative systems.

Course contents

Tissue Biochemistry

Liver. Functions and metabolic flexibility. Glucidic metabolism. Lipid metabolism. Protein metabolism. Detossification of xenobiotics. Protection from Oxidative damage. Ethanol metabolism.

Hepatic Glycogenosis, Glucide metabolism disorders (Disorders of galactose and fructose metabolism, Favism)

Non-alcoholic fatty liver disease

Interpretation of blood tests: liver function, renal function, lipid profile, complete blood count

Muscle. Skeletal and cardiac muscle metabolism. Bioenergetics: system of energy buffers "phosphocreatine shuttle" model.

Muscle Glycogenosis

Readings/Bibliography

biochemistry text books

D. Voet

J. Voet

C. W. Pratt

ZANICHELLI

specific scientific papers and handouts will be given by the teacher

Teaching methods

frontal lessons

As concerns the teaching methods of this course unit, all students (including all the international incoming exchange students, i.e. ERASMUS) must attend Module 1, 2 online [https://www.unibo.it/it/servizi-e-opportunita/salute-e-assistenza/salute-e-sicurezza/sicurezza-e-salute-nei-luoghi-di-studio-e-tirocinio], while Module 3 on health and safety is to be attended in class. Information about Module 3 attendance schedule is available on the website of your degree programme ("studiare"--"formazione obbligatoria su sicurezza e salute").

Assessment methods

WRITTEN TEST WITH 25 MULTIPLE-CHOICE QUESTIONS.EACH QUESTION HAS THREE ANSWERS OF WHICH ONLY ONE IS CORRECT. EACH CORRECT ANSWER SCOREs ONE POINT. 25 CORRECT ANSWERS EQUAL PRAISE. THE TIME ALLOCATED TO EACH STUDENT FOR CARRYING OUT THE WRITTEN TEST IS 25 MINUTES. THE QUESTIONS COVER THE WHOLE PROGRAM AND ARE ABOUT 2/3 QUESTIONS TO VERIFY THE TOPICS OF THE PROGRAM AND FOR THE REMAINING 1/3 MORE ARTICULATED QUESTIONS FOR IN-DEPTH CONCEPTUAL DEVELOPMENT OF THE TOPICS COVERED IN LESSON.

Teaching tools

Teaching material such as slides, animations, films used during lessons will be made available to studens. The printable material should be taken by the student to class.

Office hours

See the website of Stefano Iotti