08956 - Clinical Biochemistry

Learning outcomes

The student, at the end of the module, thanks to the knowledge of the fundamental principles of chemistry and organic molecules of biological interest, is able to evaluate biological and biochemical parameters in biological samples and in vivo, also in relation to pathophysiological states, at different levels of structural organization, from single molecules to cells, tissues, organs, up to the whole organism.

Course contents

• Biomarkers: definition and types; development and validation of biomarkers; performance of a test.
  
• Precision medicine: definitions; role of biomarkers in precision medicine; molecular diagnostics techniques and their applications; next-generation sequencing.
  
• Epigenetics: principles; epigenetic biomarkers.
• Liquid biopsy: biomarkers based on circulating nucleic acids.

 

Readings/Bibliography

• Teaching materials in pdf
• M. Ciaccio e G. Lippi, Biochimica Clinica e Medicina di Laboratorio, EDISES

Teaching methods

Lectures with powerpoint presentations

Assessment methods

Assessment of learning takes place only through the final exam, which ascertains the acquisition of the expected knowledge and skills. The exam is unique for the Integrated Course of Pathological Sciences, in written form and consists of 60 multiple choice questions (30 of Pathology and Immunology, 10 of Clinical Pathology, 10 of Clinical Biochemistry and 10 of General Pharmacology) to be answered in 50 minutes.

The exam takes place on the computer in the computer room.

The minimum mark of 18/30 is achieved with 36 correct answers. The final grade is calculated as the arithmetic average of the positive results of the various modules that make up the integrated course.

Teaching tools

Power point presentations, video

Office hours

See the website of Maria Giulia Bacalini