00351 - Pharmacology

Learning outcomes

The main objective of this course of Pharmacology is to provide basic knowledge on the following items:

• phamacokinetics: absorption, metabolism, distribution and elimination of drugs; routes of administration and pharmacokinetic parameters;
• pharmacodynamics: mechanisms of action of drugs, drug-receptor interaction, dose-response relationship;
• therapeutic index and benefit-risk balance of drugs;
• drug interactions and other factors modifying drug effects;
• classes of drugs of interest in dentistry.

Course contents

GENERAL PHARMACOLOGY

Drug development and marketing authorization of medicinal products in the European Union

PHARMACOKINETICS

- Routes of drug administration

- Absorption and distribution of drugs in the body

- Clearance: biotransformation and elimination

- Pharmacokinetics after single and repeated dosing

PHARMACODYNAMICS

- Mechanisms of drug action (receptors and other mechanisms)

- Dose-response relationship

- Agonists and antagonists

- Variability in drug response an drug interactions

SYSTEM PHARMACOLOGY and CLINICAL PHARMACOLOGY

- Drugs acting on the autonomic nervous system

- Benzodiazepines

- Antidepressants

- Drugs used in analgesia

- Diuretics

- ACE inhibitors and angiotensin II receptor antagonists

- Beta-blockers

- Calcium-channel blockers

- Agents used in angina pectoris

- Agents used in dyslipidemias

- Inhibitors of platelet aggregation, anticoagulants, trombolytics, antihemorragic agents,

- Agents used in osteoporosis

- Bronchodilators and other agents used in asthma and COPD

- Drugs used in allergic rhinitis

- Drugs used in peptic ulcer

- Glucocorticoids

- Non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol

- Antihistamines

- Antidiabetic agents

- Estrogens, progestins and androgens

Readings/Bibliography

1) Goodman & Gilman, Le basi farmacologiche della terapia, Il Manuale, II Edizione italiana, Zanichelli, 2015.

2) Govoni S, Farmacologia. Casa editrice Ambrosiana, 2014.

Teaching methods

Lectures

Assessment methods

Oral examination to assess achievement of the skills detailed in the learning outcomes (see the Italian version for details)

Teaching tools

Teaching material (restricted to UNIBO students) can be downloaded from the institutional repository (virtuale.unibo.it).

Office hours

See the website of Domenico Motola

See the website of Emanuel Raschi