07732 - Clinical Pathology

Learning outcomes

To allow the students to acquire the fundamental notions for a critical evaluation and interpretation of the results of the main clinical laboratory tests.

Course contents

- Laboratory test for the diagnosis of coagulation disorders. Laboratory tests for the evaluation of platelet function and coagulation cascade; laboratory definition of the hypercoagulability disorders (4 hours).

- Serum proteins. Serum protein electrophoresis (SPE); SPE patterns associated to specific diseases; acute phase reactants (APRs) and erythrocyte sedimentation rate (ESR).

- Laboratory tests for the diagnosis of lipid disorders. Plasma lipoproteins and their metabolism; lipoproteins and atherosclerosis; quantitative and qualitative analysis of plasma lipoproteins.

- Laboratory tests for the diagnosis of diabetes. Classification of diabetes; metabolic effect of diabetes; laboratory tests for the diagnosis and for the follow-up of diabetic patients.

- Laboratory tests for the diagnosis of acid-base disorders. Respiratory and metabolic acidosis and alkalosis; blood gas analysis in the simple and complex disruptions of acid-base balance.

- Laboratory tests for the diagnosis of hepatic disorders. Bilirubin and urobilinogen; serum enzymes indicative of cytolysis and cholestasis; albumin/globulin ratio; coagulation factors.

- Laboratory tests for the diagnosis of renal system disorders. Urine analysis (physical, chemical and microscopic examination); urea, creatinine and uric acid; clearance tests; functional tests.

Readings/Bibliography

Readings/Bibliography

- Marcello Ciaccio e Giuseppe Lippi: Biochimica Clinica e Medicina di Laboratorio. Terza edizione, 2020 EdiSES Università S.r.l . - Napoli.

- Italo Antonozzi e Elio Gulletta: Medicina di Laboratorio: Logica & Patologia Clinica. Terza edizione, 2019 Piccin Nuova Libraria S.p.A. Padova.

Office hours

See the website of Tommaso Fasano