- Docente: Carlo Gostoli
- Credits: 6
- SSD: ING-IND/24
- Language: Italian
- Moduli: Carlo Gostoli (Modulo 1) Serena Bandini (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Chemical and Process Engineering (cod. 0929)
Learning outcomes
The course introduces to the engineering problems relating to bioprocesses and to membrane technology.
Course contents
Bioreactores:
1. Introduction: something about biochemistry and cell biology (based on the knowledge gained in previous courses). 2. Enzyme kinetics, inhibition, effect of pH and temperature, deactivation. 3. Cell growth, growth stoichiometry (yield factors), Monod kinetics. 4. Continuous stirred tank fermenter, nonideal mixing, CSTF with cell recycling. 5. Examples of industrial processes: baker yeast, growth-associated products, antibiotics, enzymes. 6. Fermentation technology: medium formulation, design and operation of a typical aseptic fermentation process. 7. Transport phenomena in bioprocess systems, agitation and aeration in bioreactors. 8. Sterilization of culture media and air, Cleaning in place.
Membranes:
.1. Introduction: separation processes in general, the role of membrane technology in process industry, water treatment, biotechnology etc- 2. Definition and classification of membrane separation processes: short description of the various techniques, the concept of cross flow filtration. 3. Porous membranes: bubble point and penetration pressure. 4. Osmotic pressure of solutions, water activity, van't Hoff law. 5. Membranes structure and properties: asymmetric and composite membranes, membrane manufacturing. 6. membrane modules: plate and frame, spiral wound, tubular, capillary, hollow fiber. 7 Mass transfer through membranes: the solution-diffusion model. 8 Concentration polarization in reverse osmosis, the film model. 9. Analysis of reverse osmosis modules. 10. Nanofiltration. 11. Ultrafiltration: the gel model, applications, diafiltration 12. Gas separation. 13. Pervaporation and vapor permeation. 14. Membrane contactors. 15. Emerging membrane processes. 16 Membrane bioreactors.
Readings/Bibliography
- Appunti del docente
- Michael L. Shuler M.L., Kargi F. Bioprocess Engineering: Basic Concepts. Second Edition Prentice Hall), 2002.
- Blanch H.W., Clark D. S., Biochemical engineering, M. Dekker 1997.
- Bailey J.E., Ollis D.F., Biochemical Engineering Fundamentals, McGraw-Hill, 1986
- Cheryan M., Ultrafiltration and microfiltration handbook, Technomic, 1998
- Rautenbach R., Albert R., Membrane processes, John Wiley 1989
- Winston Ho W.S., Sirkar K.K., Membrane Handboob, Van Nostrand Reinhold, 1992
Assessment methods
Oral exam
Office hours
See the website of Carlo Gostoli
See the website of Serena Bandini